-What is the efficacy of orthobiologics?

Orthobiologics base therapies have shown noticeable clinical results at the short and midterm. The optimal design for a successful scaffold remains to be further determined.

Use of orthobiologics for Osteoarthritis

This debilitating disorder is associated with pain and decreased physical function. Though total joint arthroplasty is generally successful, this procedure has associated risk and many patients still have residual pain.

Nonoperative treatments have been investigated to provide patients with durable pain relief with lower levels of associated risks.

Orthobiologics, such as platelet-rich plasma, bone marrow aspirate concentrate and amniotic products, contain cytokines and/or mesenchymal progenitor cells that have been demonstrated to modulate the pathogenesis of osteoarthritis and may provide clinical improvement in the clinical setting.

Disease-modifying effects of arthobiologics in the treatment of knees osteoarthritis

It is estimated that > 500 million people worldwide are affected by knee osteoarthritis.

Management of this condition is still a challenging task well into the twenty-first century. Minimally manipulated cell-based products, such as those derived from adipose tissue and bone marrow, are reported to be effective in mild to moderate knee osteoarthritis.